Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Moderately Good
Based on 39 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
Read More
8
We examined the effects of coenzyme Q10 (CoQ10) on chronic fatigue syndrome (CFS) to understand its potential benefits for individuals suffering from this condition. Our investigation highlighted how CoQ10 could possibly alleviate some symptoms related to CFS, such as fatigue and exercise intolerance, which many patients experience.
CoQ10 acts as a powerful antioxidant, playing an essential role in how our cells generate energy. By supplementing with CoQ10, studies suggest that patients may see improvements in overall quality of life, including reduced feelings of tiredness and enhanced performance during physical activities.
The evidence indicates a positive relationship between CoQ10 supplementation and decreased fatigue levels in those with chronic fatigue syndrome. By helping to minimize oxidative stress and protect mitochondrial function, CoQ10 might provide significant relief to sufferers of CFS, making it a promising candidate for future therapeutic strategies.
Overall, our findings suggest that coenzyme Q10 could offer a valuable option for managing chronic fatigue syndrome, providing hope for those looking for effective treatment approaches.
CoQ10 acts as a powerful antioxidant, playing an essential role in how our cells generate energy. By supplementing with CoQ10, studies suggest that patients may see improvements in overall quality of life, including reduced feelings of tiredness and enhanced performance during physical activities.
The evidence indicates a positive relationship between CoQ10 supplementation and decreased fatigue levels in those with chronic fatigue syndrome. By helping to minimize oxidative stress and protect mitochondrial function, CoQ10 might provide significant relief to sufferers of CFS, making it a promising candidate for future therapeutic strategies.
Overall, our findings suggest that coenzyme Q10 could offer a valuable option for managing chronic fatigue syndrome, providing hope for those looking for effective treatment approaches.
Read More
8
CoQ10 Shows Heart Function Improvement
We investigated the effects of coenzyme Q10 (CoQ10) treatment on patients experiencing chronic fatigue syndrome and related symptoms. In a comprehensive study, 115 patients presented with fatigue, precordial pain, and arrhythmias, which are often precursors to heart failure. Among these individuals, those with chronic fatigue syndrome were evaluated alongside groups with hypertensive cardiovascular disease and mitral valve prolapse syndrome.
We recorded key health metrics, including blood pressure, CoQ10 blood levels, and echocardiographic measurements that assess both diastolic and systolic heart function. The participants were then given CoQ10 supplements, and we conducted follow-up evaluations to measure any changes.
The treatment resulted in promising enhancements across the board—eighty percent of hypertensive patients experienced lowered blood pressure, while all participants showed improved diastolic functioning. Moreover, more than half of the hypertensive group saw a reduction in myocardial thickness. However, while the results were favorable for various heart-related conditions, we noted that the information does not isolate the effects specifically for chronic fatigue syndrome, limiting our understanding of CoQ10’s isolated efficacy for this group.
Overall, the initial trial indicates that CoQ10 could potentially benefit heart function, which may help alleviate some symptoms associated with chronic fatigue syndrome, although more focused studies are needed to draw definitive conclusions for this specific condition.
We recorded key health metrics, including blood pressure, CoQ10 blood levels, and echocardiographic measurements that assess both diastolic and systolic heart function. The participants were then given CoQ10 supplements, and we conducted follow-up evaluations to measure any changes.
The treatment resulted in promising enhancements across the board—eighty percent of hypertensive patients experienced lowered blood pressure, while all participants showed improved diastolic functioning. Moreover, more than half of the hypertensive group saw a reduction in myocardial thickness. However, while the results were favorable for various heart-related conditions, we noted that the information does not isolate the effects specifically for chronic fatigue syndrome, limiting our understanding of CoQ10’s isolated efficacy for this group.
Overall, the initial trial indicates that CoQ10 could potentially benefit heart function, which may help alleviate some symptoms associated with chronic fatigue syndrome, although more focused studies are needed to draw definitive conclusions for this specific condition.
Read More
Most Useful Reviews
9
Rejuvenating energy
14 people found this helpful
This supplement truly provides ENERGY! CoQ10 improves cardiovascular health, has a rejuvenating effect, enhances carbohydrate metabolism, and boosts the immune system. I take it alongside Omega and Resveratrol. After a month, I felt noticeable improvements in my well-being and energy, with deeper sleep and a stable mood. I plan to keep incorporating it into my routine.
Read More
9
Chronic fatigue relief
11 people found this helpful
It’s no coincidence that someone received a Nobel Prize related to this supplement. Coenzyme Q10 has been a wonderful solution for my chronic fatigue syndrome. I hope this effect lasts a bit longer as many remedies have proven ineffective over the years.
Read More
9
Marked improvement
5 people found this helpful
After three months of taking this supplement, my condition has greatly improved, enabling me to train again and get better sleep. I've lost 8 kg and found it helpful for my chronic fatigue syndrome.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
- All Researches
9
We examined the impact of coenzyme Q10, combined with alpha lipoic acid, on individuals suffering from chronic COVID syndrome, which features symptoms similar to chronic fatigue syndrome. The study involved 174 patients, who were divided into two groups.
One group received the combined treatment, while the other group did not receive any treatment at all. Our focus was primarily on how well the treatment reduced fatigue, measured using the Fatigue Severity Scale (FSS).
The results were quite striking: a majority of those who received the treatment showed a significant reduction in fatigue compared to those who did not. In fact, over 53% of patients in the treatment group reported a complete response, whereas only a small fraction in the control group achieved similar results.
Overall, our findings indicate a positive effect of coenzyme Q10 and alpha lipoic acid on reducing chronic fatigue symptoms associated with chronic COVID. However, to validate these results further, we believe that a double-blind, placebo-controlled trial would be essential for confirming the effectiveness of this treatment approach.
One group received the combined treatment, while the other group did not receive any treatment at all. Our focus was primarily on how well the treatment reduced fatigue, measured using the Fatigue Severity Scale (FSS).
The results were quite striking: a majority of those who received the treatment showed a significant reduction in fatigue compared to those who did not. In fact, over 53% of patients in the treatment group reported a complete response, whereas only a small fraction in the control group achieved similar results.
Overall, our findings indicate a positive effect of coenzyme Q10 and alpha lipoic acid on reducing chronic fatigue symptoms associated with chronic COVID. However, to validate these results further, we believe that a double-blind, placebo-controlled trial would be essential for confirming the effectiveness of this treatment approach.
Read More
We conducted a thorough study to explore how coenzyme Q10, combined with NADH, can alleviate symptoms of chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME/CFS). In a well-structured, 12-week randomized, double-blind, placebo-controlled trial, we enrolled 207 patients suffering from ME/CFS. Participants were split into two groups, with one receiving a daily dose of 200 mg CoQ10 and 20 mg NADH, while the other took a matching placebo.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
Read More
8
We observed intriguing effects of micronutrient supplementation, including coenzyme Q10, on chronic fatigue syndrome. The studies analyzed provided a comprehensive look at how these supplements might enhance energy levels and promote overall wellbeing.
In several well-conducted trials, participants receiving a combination of multiple micronutrients with coenzyme Q10 showed reduced oxidative stress. This was particularly noted in those experiencing chronic fatigue syndrome. Additionally, healthy individuals demonstrated increased cerebral blood flow, enhanced energy expenditure, and improved fat oxidation when supplemented.
Participants also reported less mental and physical fatigue and found improvements in their cognitive performance during demanding tasks. The collective findings suggest that bolstering our diets with these supplements can offer significant benefits, especially in regions where micronutrient deficiencies are prevalent, even among those who generally eat well.
Overall, this evidence underscores the potential of coenzyme Q10 when used alongside other micronutrients to help improve nutritional status, energy metabolism, and subjective wellbeing in individuals facing chronic fatigue syndrome.
In several well-conducted trials, participants receiving a combination of multiple micronutrients with coenzyme Q10 showed reduced oxidative stress. This was particularly noted in those experiencing chronic fatigue syndrome. Additionally, healthy individuals demonstrated increased cerebral blood flow, enhanced energy expenditure, and improved fat oxidation when supplemented.
Participants also reported less mental and physical fatigue and found improvements in their cognitive performance during demanding tasks. The collective findings suggest that bolstering our diets with these supplements can offer significant benefits, especially in regions where micronutrient deficiencies are prevalent, even among those who generally eat well.
Overall, this evidence underscores the potential of coenzyme Q10 when used alongside other micronutrients to help improve nutritional status, energy metabolism, and subjective wellbeing in individuals facing chronic fatigue syndrome.
Read More
8
We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
Read More
We conducted a thorough evaluation of how coenzyme Q10 (CoQ10) combined with nicotinamide adenine dinucleotide (NADH) affects individuals with Chronic Fatigue Syndrome (CFS). A proof-of-concept trial ran for eight weeks with 80 CFS patients, who were randomly assigned to receive either the CoQ10 and NADH supplement or a placebo. This method ensured that our results were reliable, as both patients and researchers were unaware of which group received the supplement or the placebo, making it a double-blind study.
Our primary focus was to measure the effect on age-predicted maximum heart rate (max HR) during exercise tests. Alongside this, we also looked at secondary factors including levels of fatigue, pain, and sleep quality. After the eight-week period, we found that individuals who took the CoQ10 and NADH combination showed a reduction in max HR during the cycle ergometer test. Additionally, they reported improvements in fatigue levels.
These results are promising as they suggest that this combination could be safe and potentially effective for reducing both heart rate responses to exertion and overall fatigue in CFS patients. However, we recognize the need for larger controlled trials to further validate these findings before drawing definitive conclusions.
Our primary focus was to measure the effect on age-predicted maximum heart rate (max HR) during exercise tests. Alongside this, we also looked at secondary factors including levels of fatigue, pain, and sleep quality. After the eight-week period, we found that individuals who took the CoQ10 and NADH combination showed a reduction in max HR during the cycle ergometer test. Additionally, they reported improvements in fatigue levels.
These results are promising as they suggest that this combination could be safe and potentially effective for reducing both heart rate responses to exertion and overall fatigue in CFS patients. However, we recognize the need for larger controlled trials to further validate these findings before drawing definitive conclusions.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 39 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Rejuvenating energy
14 people found this helpful
This supplement truly provides ENERGY! CoQ10 improves cardiovascular health, has a rejuvenating effect, enhances carbohydrate metabolism, and boosts the immune system. I take it alongside Omega and Resveratrol. After a month, I felt noticeable improvements in my well-being and energy, with deeper sleep and a stable mood. I plan to keep incorporating it into my routine.
Read More
9
Chronic fatigue relief
11 people found this helpful
It’s no coincidence that someone received a Nobel Prize related to this supplement. Coenzyme Q10 has been a wonderful solution for my chronic fatigue syndrome. I hope this effect lasts a bit longer as many remedies have proven ineffective over the years.
Read More
9
Marked improvement
5 people found this helpful
After three months of taking this supplement, my condition has greatly improved, enabling me to train again and get better sleep. I've lost 8 kg and found it helpful for my chronic fatigue syndrome.
Read More
9
Alleviated fatigue
1 people found this helpful
This product is fantastic for my chronic fatigue syndrome caused by my connective tissue disease. I can't go a day without it, and its quality-to-price ratio is the best.
Read More
9
Enhanced energy
1 people found this helpful
Coenzyme Q10 is a powerful antioxidant. I ordered it for my mother as she faced chronic fatigue syndrome and liver issues. It promotes energy production and reduces fatigue.
Read More
Frequently Asked Questions
9
Rejuvenating energy
14 people found this helpful
This supplement truly provides ENERGY! CoQ10 improves cardiovascular health, has a rejuvenating effect, enhances carbohydrate metabolism, and boosts the immune system. I take it alongside Omega and Resveratrol. After a month, I felt noticeable improvements in my well-being and energy, with deeper sleep and a stable mood. I plan to keep incorporating it into my routine.
9
Marked improvement
5 people found this helpful
After three months of taking this supplement, my condition has greatly improved, enabling me to train again and get better sleep. I've lost 8 kg and found it helpful for my chronic fatigue syndrome.
9
Improved mood
After two months of use, I have seen marked improvement in my condition. My energy levels have risen, my fatigue has vanished, and my emotional state is much better. Having returned to work after three years of maternity leave, I feel more resilient in this stressful environment. I highly recommend this product and plan to order more.
9
Reduced fatigue
1 people found this helpful
Thank you, CoQ10, for rejuvenating me as a tired 50-year-old. I regret not taking it earlier. After some tests showed normal results, I learned about CoQ10's benefits. I began with 100mg for five days, then increased to 200mg, which noticeably improved my fatigue from day three. I plan to continue taking CoQ10, as it’s recognised for its effectiveness in treating chronic fatigue syndrome, especially for those over 50.
7.5
Boosted energy
1 people found this helpful
I bought this supplement due to constant fatigue. Upon taking the first capsule, I felt a significant energy boost, even though it’s said to act gradually. I wholeheartedly recommend it.
7.5
Enhanced vitality
From reviews, many report increased energy and improved health after taking CoQ10. While I can’t definitively say this supplement provides such effects, I definitely feel it aids my body, especially managing my chronic fatigue syndrome.
9
Diet success
1 people found this helpful
I successfully went on a diet while taking it with carnitine and alpha lipoic acid. I didn't feel tired, and my skin improved. I trust this manufacturer for quality, so I might try ubiquinol next, hoping it helps with chronic fatigue syndrome.
6
Antioxidant recovery
3 people found this helpful
Interested in fatigue recovery, I chose this supplement due to its high antioxidant content. I read that CoQ10 works well with selenium and vitamin D to combat chronic fatigue syndrome symptoms. I'm satisfied with the packaging and ingredients.
We examined whether the combination of coenzyme Q10 (CoQ10) and selenium could improve clinical outcomes for individuals suffering from Chronic Fatigue Syndrome (CFS). In our study, 27 patients took an oral supplement of 400 mg of CoQ10 and 200 μg of selenium daily for eight weeks. We focused on patient-reported changes in fatigue severity and quality of life while keeping an eye on several circulating biomarkers.
After this eight-week period, we observed significant improvements in fatigue and overall quality of life. Participants reported feeling better, which is always encouraging. In terms of oxidative stress, we noticed a boost in total antioxidant capacity and a reduction in harmful lipoperoxide levels, both suggesting a positive shift in the body’s oxidative balance. Interestingly, although inflammatory markers showed a decrease, some important biomarkers remained unchanged.
This exploration into long-term supplementation indicates that CoQ10 and selenium may work together beneficially, providing hope for those grappling with CFS. However, we should note that while improvements were there, the effects were not uniform across all measures. It provides a valuable foundation for further research in this area.
After this eight-week period, we observed significant improvements in fatigue and overall quality of life. Participants reported feeling better, which is always encouraging. In terms of oxidative stress, we noticed a boost in total antioxidant capacity and a reduction in harmful lipoperoxide levels, both suggesting a positive shift in the body’s oxidative balance. Interestingly, although inflammatory markers showed a decrease, some important biomarkers remained unchanged.
This exploration into long-term supplementation indicates that CoQ10 and selenium may work together beneficially, providing hope for those grappling with CFS. However, we should note that while improvements were there, the effects were not uniform across all measures. It provides a valuable foundation for further research in this area.
7
We explored the potential impact of coenzyme Q10 on chronic fatigue syndrome (CFS) through a systematic review of existing studies. The aim was to find out if this popular supplement could help improve symptoms such as fatigue and overall quality of life for those affected by CFS.
Seventeen studies met our criteria for inclusion, each investigating various dietary modifications and nutritional supplements. Among them, coenzyme Q10 was evaluated in conjunction with another supplement, nicotinamide adenine dinucleotide hydride (NADH). While some improvements in fatigue were noted with this combined approach, we need to be clear that the evidence did not strongly support the isolated effectiveness of coenzyme Q10 alone for CFS symptoms.
Overall, we found insufficient evidence to confirm that coenzyme Q10, on its own or in combination, offers significant therapeutic benefits for patients with chronic fatigue syndrome. Hence, more targeted research focusing on CFS populations is needed to paint a clearer picture of how coenzyme Q10 and other nutritional interventions might fit into treatment strategies.
Seventeen studies met our criteria for inclusion, each investigating various dietary modifications and nutritional supplements. Among them, coenzyme Q10 was evaluated in conjunction with another supplement, nicotinamide adenine dinucleotide hydride (NADH). While some improvements in fatigue were noted with this combined approach, we need to be clear that the evidence did not strongly support the isolated effectiveness of coenzyme Q10 alone for CFS symptoms.
Overall, we found insufficient evidence to confirm that coenzyme Q10, on its own or in combination, offers significant therapeutic benefits for patients with chronic fatigue syndrome. Hence, more targeted research focusing on CFS populations is needed to paint a clearer picture of how coenzyme Q10 and other nutritional interventions might fit into treatment strategies.
We conducted a thorough study to explore how coenzyme Q10, combined with NADH, can alleviate symptoms of chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME/CFS). In a well-structured, 12-week randomized, double-blind, placebo-controlled trial, we enrolled 207 patients suffering from ME/CFS. Participants were split into two groups, with one receiving a daily dose of 200 mg CoQ10 and 20 mg NADH, while the other took a matching placebo.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
We conducted a thorough evaluation of how coenzyme Q10 (CoQ10) combined with nicotinamide adenine dinucleotide (NADH) affects individuals with Chronic Fatigue Syndrome (CFS). A proof-of-concept trial ran for eight weeks with 80 CFS patients, who were randomly assigned to receive either the CoQ10 and NADH supplement or a placebo. This method ensured that our results were reliable, as both patients and researchers were unaware of which group received the supplement or the placebo, making it a double-blind study.
Our primary focus was to measure the effect on age-predicted maximum heart rate (max HR) during exercise tests. Alongside this, we also looked at secondary factors including levels of fatigue, pain, and sleep quality. After the eight-week period, we found that individuals who took the CoQ10 and NADH combination showed a reduction in max HR during the cycle ergometer test. Additionally, they reported improvements in fatigue levels.
These results are promising as they suggest that this combination could be safe and potentially effective for reducing both heart rate responses to exertion and overall fatigue in CFS patients. However, we recognize the need for larger controlled trials to further validate these findings before drawing definitive conclusions.
Our primary focus was to measure the effect on age-predicted maximum heart rate (max HR) during exercise tests. Alongside this, we also looked at secondary factors including levels of fatigue, pain, and sleep quality. After the eight-week period, we found that individuals who took the CoQ10 and NADH combination showed a reduction in max HR during the cycle ergometer test. Additionally, they reported improvements in fatigue levels.
These results are promising as they suggest that this combination could be safe and potentially effective for reducing both heart rate responses to exertion and overall fatigue in CFS patients. However, we recognize the need for larger controlled trials to further validate these findings before drawing definitive conclusions.
7
We explored the role of coenzyme Q10 (CoQ10) in treating chronic fatigue syndrome (CFS), a complex condition often marked by debilitating fatigue. Our analysis draws from several studies assessing various dietary supplements, including CoQ10, and we put a spotlight on its effects specifically related to fatigue.
Among the fourteen studies reviewed, some reported positive outcomes with CoQ10, especially when combined with other treatments. However, the variations in study designs and the presence of methodological issues, like small sample sizes, made it difficult to draw any concrete conclusions about its efficacy.
While inconsistent results surfaced regarding enhancements in energy levels, we also noted several adverse effects reported by participants, such as nausea and insomnia. Thus, while CoQ10 shows promise, we need more rigorous research to better understand its potential benefits for CFS.
Among the fourteen studies reviewed, some reported positive outcomes with CoQ10, especially when combined with other treatments. However, the variations in study designs and the presence of methodological issues, like small sample sizes, made it difficult to draw any concrete conclusions about its efficacy.
While inconsistent results surfaced regarding enhancements in energy levels, we also noted several adverse effects reported by participants, such as nausea and insomnia. Thus, while CoQ10 shows promise, we need more rigorous research to better understand its potential benefits for CFS.
References
- Dorczok MC, Mittmann G, Mossaheb N, Schrank B, Bartova L, et al. Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review. Nutrients. 2025;17. doi:10.3390/nu17030475
- Barletta MA, Marino G, Spagnolo B, Bianchi FP, Falappone PCF, et al. Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome. Clin Exp Med. 2023;23:667. doi:10.1007/s10238-022-00871-8
- Castro-Marrero J, Domingo JC, Cordobilla B, Ferrer R, Giralt M, et al. Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?. Antioxid Redox Signal. 2022;36:729. doi:10.1089/ars.2022.0018
- Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, et al. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13. doi:10.3390/nu13082658
- Maggini S, Óvári V, Ferreres Giménez I, Pueyo Alamán MG. Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing. Nutr Hosp. 2021;38:3. doi:10.20960/nh.03788
- Campagnolo N, Johnston S, Collatz A, Staines D, Marshall-Gradisnik S. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review. J Hum Nutr Diet. 2017;30:247. doi:10.1111/jhn.12435
- Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors. 2016;42:431. doi:10.1002/biof.1293
- Castro-Marrero J, Sáez-Francàs N, Segundo MJ, Calvo N, Faro M, et al. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial. Clin Nutr. 2016;35:826. doi:10.1016/j.clnu.2015.07.010
- Castro-Marrero J, Cordero MD, Segundo MJ, Sáez-Francàs N, Calvo N, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?. Antioxid Redox Signal. 2015;22:679. doi:10.1089/ars.2014.6181
- Nicolson GL. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Altern Ther Health Med. 2014;20 Suppl 1:18.
- Cordero MD, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, et al. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Antioxid Redox Signal. 2014;20:1169. doi:10.1089/ars.2013.5198
- Morris G, Anderson G, Berk M, Maes M. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. Mol Neurobiol. 2013;48:883. doi:10.1007/s12035-013-8477-8
- Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, et al. Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett. 2009;30:470.
- Bentler SE, Hartz AJ, Kuhn EM. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005;66:625.
- Langsjoen PH, Langsjoen PH, Folkers K. Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment. Clin Investig. 1993;71:S140.
